1 edition of Aspartic acid proteases as therapeutic targets found in the catalog.
Aspartic acid proteases as therapeutic targets
Ghosh, Arun K. Prof. Dr
Includes bibliographical references and index.
|Statement||edited by Arun K. Ghosh|
|Series||Methods and principles in medicinal chemistry -- v. 45, Methods and principles in medicinal chemistry -- v. 45.|
|LC Classifications||QP609.A86 A84 2010|
|The Physical Object|
|Pagination||xxiii, 615 p. :|
|Number of Pages||615|
|LC Control Number||2011377611|
This toxic effect was attributed to off-target effects of LY (31) against other aspartic acid proteases, namely CatD, as demonstrated by a subsequent study using LY (31) in BACE1 _/_ mice. As a safety procedure, all the study participants were contacted for follow-up exams 6–10 months after conclusion of the by: 5. Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; consequently, host proteases have been the focus of intense investigation as potential therapeutic targets. A wide range of viruses encode proteases which play an essential role in Cited by: 1.
The distribution of protease genes differs widely among human chromosomes, as shown in the figure: green dots represent aspartic proteases, blue dots represent cysteine proteases, red dots Cited by: The book provides vital diagnostic information in a convenient tabular format that leaves "no stone Aspartic Acid Proteases as Therapeutic Targets, Volume Related e-Books (7 review) Campbell-Walsh Urology. Medical. Pages. (7 review) Misch's Contemporary Implant Dentistry.
(), Book chapter 12 in Aspartic Acid Proteases as Therapeutic Targets: 45 (Methods and Principles in Medicinal Chemistry) eds R. Mannhold, H. Kubinyi, G. Folkers and A.K. Ghosh, Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. Therapeutic Programs For Musculoskeletal Disorders - Wyss, James F., M.d. Edt Theory And - $ Theory And Practice Of Therapeutic Massage, Beck, Mark F., Good Book.
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About this book In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition.
Buy Aspartic Acid Proteases as Therapeutic Targets (Methods and Principles in Medicinal Chemistry Book 45): Read Kindle Store Reviews - ufacturer: Wiley-VCH. Aspartic Acid Proteases as Therapeutic Targets (Methods and Principles in Medicinal Chemistry) 1st Edition by Arun K.
Ghosh (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) & 1 moreAuthor: Arun K. Ghosh. The NOOK Book (eBook) of the Aspartic Acid Proteases as Therapeutic Targets by Arun K.
Ghosh at Barnes & Noble. FREE Shipping on $35 or more. Due to COVID, orders may be : Arun K. Ghosh. Request PDF | Aspartic Acid Proteases as Therapeutic Targets | IntroductionSequence Alignment and Family TreeThree-Dimensional StructureConferences and ProgressExploration of the Active Sites of.
Aspartic Acid Proteases as Therapeutic Targets (Methods and Principles in Medicinal Chemistry Book 45) eBook: Ghosh, Arun K.: : Kindle StoreManufacturer: Wiley-VCH. ISBN: OCLC Number: Description: xxiii, pages: illustrations: Contents: OVERVIEW OF ASPARTIC ACID PROTEASES Introduction to the Aspartic Proteases Family Aspartic Acid Proteases, Structure, Function and Inhibition Human Aspartic Proteinases Structure-based Drug Design Strategies for the Inhibition of Aspartic Acid Proteases HIV.
Download Citation | Aspartic Acid Proteases as Therapeutic Targets | In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's.
Get this from a library. Aspartic Acid Proteases as Therapeutic Targets. [Arun K Ghosh; Raimund Mannhold; Hugo Kubinyi] -- In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of.
Aspartic proteases are a class of endopeptidases that generally have a bi-lobal structure, with each lobe contributing an aspartic acid residue to the active site of the enzyme. Cathepsin d -like aspartic proteases are members of the A1 family of aspartic proteases and. This book focuses on the aspartic proteinase family of proteolytic enzymes and speciﬁcally on several enzymes that are currently being pursued as drug targets for therapeutic intervention in humans.
Aspartic Proteases: Structure, Function, and Inhibition Jordan Tang Oklahoma Medical Research, Foundation and University of Oklahoma, Health Science Center, Cited by: 3.
Title:Development of Trypsin-Like Serine Protease Inhibitors as Therapeutic Agents: Opportunities, Challenges, and their Unique Structure-Based Rationales VOLUME: 16 ISSUE: 13 Author(s):Guyan Liang and J. Phillip Bowen Affiliation:Budd Larner PC, John F.
Kennedy Pkwy, Short Hills, NJ Keywords:Anticoagulants, Apixaban (Eliquis ®), Catalytic triad (His57, Asp, Ser), Dabigatran Cited by: 4. Parts two through five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase, plasmepsins, and fungal proteases.
In this scenario, understanding of the proteases, how they are involved in early to the end point in cancer progression is needed. In this review, we will focus on the role of proteases as prognostic and therapeutic targets in various types of : Animesh Chowdhury, Donatella Romaniello, Soma Ghosh, Tapati Chakraborti, Soumitra Roy, Sajal Chakrab.
Author(s): Ghosh,Arun K,Prof. Title(s): Aspartic acid proteases as therapeutic targets/ edited by Arun K. Ghosh. Country of Publication: Germany Publisher. Aspartic Acid Proteases as Therapeutic Targets by Ghosh et al.
quotes him on this, but I can't get the reference on Google Books (it is omitted. 10 April (UTC). A protease (also called a peptidase or proteinase) is an enzyme that catalyzes (increases the rate of) proteolysis, the breakdown of proteins into smaller polypeptides or single amino do this by cleaving the peptide bonds within proteins by hydrolysis, a reaction where water breaks ses are involved in many biological functions, including digestion of ingested proteins.
Aspartic Acid Proteases as Therapeutic Targets (Methods and Principles in Medicinal Chemistry) Published by Wiley-VCH () ISBN ISBN Ghosh AK (ed) () Aspartic acid proteases as therapeutic targets, Methods and principles in medicinal chemistry. Wiley-VCH, Weinheim Google Scholar Greenlee WJ.
He edited a book entitled, ‘Aspartic Acid Proteases as Therapeutic Targets’ published by Wiley-VCH in He is married to his wife, Jody, an emergency physician. Proteases catalyse the hydrolyis of peptide bonds in proteins, often in a very precise way, and are thereby involved in the control of a number of important physiological processes including cell Cited by: Numerous trypsin-like serine proteases have been under active pursuit as therapeutic targets.
Important examples include thrombin, factor VIIa, factor Xa, and β-tryptase with indications ranging from thrombosis and inflammation to asthma and chronic obstructive pulmonary disease (COPD).
aspartic acidand serine A rich collection.